Abstract
Vulvovaginal candidiasis is the most prevalent vaginal infection worldwide. Considering the violence of the symptoms that some patients report, the tendency to relapse or of resistance to the azole therapy, and the success reported by some studies in the treatment with boric acid of the vaginal infection with various pathogens, we conducted a prospective study in which we used vaginal boric acid for Candida species infection. The aim of our study was to evaluate the effectiveness and tolerability of boric acid in the treatment of vaginal infection with Candida species. Analysing the data from the satisfaction questionnaire completed by the patients who reached the end of the study showed that our investigational product has a good and very good effectiveness in sterilizing the infection (71%), being considered by patients to be easily administered (67.7%), the safety of the product being perceived as good and very good by 93.6% of them.
Highlights
Vulvovaginal candidiasis is the most prevalent vaginal infection worldwide
Considering the violence of the symptoms that some patients report [2], the tendency to relapse or of resistance to the azole therapy [4], and the success reported by some studies in the treatment with boric acid of the vaginal infection with various pathogens [9,10,11,12,13,14], we conducted a study aiming to evaluate the efficacy of the boric acid vaginal suppositories in patients with documented vaginal infection for Candida spp
At visit 4, we found that 2 patients abandoned the study, and of the remaining 50 patients who were present (PP population), 42 patients tested negative at the final mycological control, while 8 patients showed signs of recurrence of symptomatology specific to candidal vaginitis, confirmed by the result of the microscopic examination of the vaginal discharge
Summary
Vulvovaginal candidiasis is the most prevalent vaginal infection worldwide. Considering the violence of the symptoms that some patients report, the tendency to relapse or of resistance to the azole therapy, and the success reported by some studies in the treatment with boric acid of the vaginal infection with various pathogens, we conducted a prospective study in which we used vaginal boric acid for Candida species infection. The antiseptic and bactericidal effects of boric acid have been demonstrated in numerous studies concerning the effectiveness of its use in the vulvovaginal infections of various etiologies [9,10,11,12,13,14], being preferred in the treatment of vaginal infections with Candida spp.
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