Abstract
The objective of this study briefly focus on the evaluation of diuretic activity and its possible mechanism of action of methanolic extract of Syzygium cumini (MESCS) seeds. The MESCS doses (150 and 300 mg/kg) were orally administered to male Wistar albino rats. Urine volume, urinary excretion, diuretic action, diuretic activity, electrolyte levels in urine, natriuretic, saluretic, and carbonic anhydrase inhibitory activity, were measured in of saline loaded rats at 5 and 24th hour. Plasma creatinine and uric acid were also measured at 24th hour. The oral administration of MESCS increased the urine volume and electrolyte excretion at the 24th hour compared to 5th hour. To assess the involvement of the prostaglandin system in the mechanism of action, oral administration of methanolic extract of S. cumini (300 mg/kg) in association with Lornoxicam (3 mg/kg) reduced urinary and sodium, potassium, and chlorine excretion when compared to MESCS group. The results concluded that MESCS shown maximum diuretic activity at a dose of 300 mg/kg 24th hour and its mechanism involved prostaglandin system.
Published Version
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