Evaluation of diuretic activity of &lt;i&gt;Paspalidium flavidum&lt;/i&gt; in rats

- Alamgeer Alamgeer,Muhammad Akram,Muhammad Rashid,Abdul Qayyum Khan,Sajid Bashir,Sadia Samreen,Muhammad Nasir Hayat Malik,Muhammad Naveed Mushtaq

doi:10.3329/bjp.v8i2.14243

Abstract

This study was conducted to investigate the diuretic potential of aqueous methanolic extract of Paspalidium flavidum in rats. The extract at doses of 10, 30 50 and 100 mg/kg was administered intraperitoneally in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. Total urine volume and urinary excretion of electrolytes were measured. Preliminary phytochemical tests were also performed using standard procedures. The extract exhibiteda significant dose dependent diuretic effect at all the doses when compared to control group. Urinary excretion of sodium was significantly increased by the extract while a significant increase in potassium excretion was only observed at higher doses. Phytochemical analysis illustrated that the extract contained compounds such as alkaloids, saponins, tannins, flavonoids, cardiac glycosides and reducing sugars. It is conceivable therefore that the aqueous methanolic extract of P. flavidum contain certain biologically active compounds that might be responsible for the diuretic activity.

Highlights

Diuretics are the drugs that promote urine production, sodium excretion and adjust volume of body fluids in various clinical situations
There was no scientific study available on the diuretic activity of this plant; this study was aimed at exploring the therapeutic potential of aqueous methanolic extract of P. flavidum in diuresis
A highly significant (p

Summary

Introduction

Diuretics are the drugs that promote urine production, sodium excretion and adjust volume of body fluids in various clinical situations They have been considered an effective treatment for diseases like hypertension, cardiac failure, nephritic syndrome and pulmonary edema (Devi et al, 2010). Despite the abundance of these synthetic drugs, a significant proportion of the population of developing countries depends on traditional ideas such as efficiency (high ceiling diuretics), place of action (loop diuretics), structure (thiazide diuretics) and effects medicines for their health related needs. This is due to the fact that the efficacy of the modern synthetic drugs has been only 60%, and generally a combination of these drugs is required to achieve optimal therapeutic outcomes. According to WHO, about 60% of the population in developed countries rely on traditional herbal medicine, and the percentage is much higher in the developing world (WHO, 2000)

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