Abstract
Dis-Lub-Tout, is a new excipient co-processed from re-generated cellulose, RC, and olive oil, OL, to act as a lubricant and disintegrant in tablets and capsules formulations. The new excipient was off-white, very fine, cohesive, greasy to the touch, readily adheres to the skin and having the characteristic OL odour. The effective mean particle diameter of the excipient was 3 μm. Dis-Lub-Tout exhibited moisture sorption isotherm more or less equal to that exhibited by re-generated cellulose lubricated with equivalent concentration of magnesium stearate. The thermo-degradation of OL in Dis-Lub-Tout followed the first order mechanism with rate constants amenable to Arrhenius treatment. The degradation under humid condition was faster and also followed the first order mechanism with rate constants depending on the amount of the water adsorbed by the tested sample. The co-processed material developed a faint rancidity odour after 12 months shelf storage.
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