Abstract
This retrospective study was designed to determine the prognostic value of a cumulative score (FA score) based on pretreatment plasma fibrinogen and serum albumin levels for 326 patients newly diagnosed high-grade glioma (HGG). Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal cut-off values. Univariate and multivariate analysis were performed to evaluate the independent prognostic value of the FA scores associated with overall survival (OS) and progression-free survival (PFS). The optimal cut-off values were 2.815 g/L for fibrinogen and 43.65 g/L for albumin. PFS and OS were significantly worse for patients with higher FA scores. Patients with elevated fibrinogen level and decreased albumin levels had 3.00-fold higher risk of tumor progression and had a 3.23-fold higher risk of death compared with those with normal values. Multivariate analysis demonstrated FA score was an independent predictive factor for PFS and OS. Moreover, PFS and OS were better for the patients with lower FA score, either in patients with grade III or IV gliomas. These findings indicated that the pretreatment FA score could serve as a simple and noninvasive marker to predict the prognosis of patients with HGG.
Highlights
High-grade gliomas (HGG), defined as World Health Organization (WHO) Grade III and IV gliomas, are the most devastating malignancies in the central nerve system
This retrospective study was designed to determine the prognostic value of a cumulative score (FA score) based on pretreatment plasma fibrinogen and serum albumin levels for 326 patients newly diagnosed high-grade glioma (HGG)
These findings indicated that the pretreatment FA score could serve as a simple and noninvasive marker to predict the prognosis of patients with HGG
Summary
High-grade gliomas (HGG), defined as World Health Organization (WHO) Grade III and IV gliomas, are the most devastating malignancies in the central nerve system. The histopathological characteristics, performance status, tumor grade, prognostic indicators based on systemic inflammation levels and nutritional conditions of patients with HGG are published [4, 5]. High pretreatment plasma fibrinogen levels are significantly associated with shorter survival in rectal cancer, non-small cell lung cancer, renal cell carcinoma and breast cancers [7,8,9,10]. Serum albumin levels are an important indicator www.impactjournals.com/oncotarget of host’s systemic inflammatory response and nutritional status as a prognostic indicator in several cancer [11,12,13]. Low serum albumin levels are associated with significantly short survival in glioblastoma patients [14]
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