Abstract
Abstract Background: Oral squamous cell carcinoma (OSCC) exhibits dysplastic features in the epithelium and connective tissue which constitute tumor microenvironment. Eosinophils are granulocytic cells which impart inflammatory response and cell death, thereby producing a great role in the regulation and progression of tumors. The morphology of collagen fibers also varies on the progression of oral cancer. Aims: The present study aims at evaluating collagen morphology and amount of eosinophil in different grades of OSCC using hematoxylin and eosin (H and E) and Congo red stains. Settings and Design: The present study includes histopathologically proven cases of 15 OSCC subclassified into five cases per each group. Subjects and Methods: Both H and E and Congo red staining were done for five cases per grades of OSCC and viewed by two observers in zigzag pattern. Statistical Analysis Used: Statistical analysis was done using ANOVA test and interobserver variability by kappa statistics. Results: P < 0.001 was obtained based on the ANOVA test and P value of eosinophils among different grades was statistically significant. Conclusions: The present study concludes that stroma will change from dense to loose and increase in number of eosinophils as carcinoma progresses.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
