Abstract
Canine parvoviral enteritis (CPE) has ahigh mortality rate inuntreated dogs due tosystemic inflammation and multi-organ dysfunction. The inflammatory process can lead tocoagulation abnormalities. This study aimed toevaluate the coagulation status using thromboelastography (TEG) and assess the thrombin generation (TG) and clot dissolution using TEG-derived velocity curve (v-curve) parameters indogs with CPE. Itincluded 21dogs with CPE and five healthy dogs. Inaddition tothe clinico-haemato-biochemical examinations, the coagulation status was analysed using citrated venous blood samples with TEG. All the dogs with CPE met atleast two criteria for systemic inflammatory response syndrome (SIRS). The comparison tohealthy controls showed astatistically significant prolongation ofreaction times (Rtime; P=0.005) and times tothe maximum rate ofthrombus generation (TMRTG; P=0.003). However, the times tothe maximum rate oflysis (TMRL; P=0.041) and total lysis (L; P=0.024) decreased significantly. The TEG tracings showed coagulation states varying from hypocoagulation tohypercoagulation indogs with CPE. These results showed that the v-curve derivate can beused toevaluate the coagulation indogs with CPE, and itcould besuperior tothe standard TEG variables for determining the low fibrinolytic activity. Thus, the v-curve parameters may provide anovel insight into the underlying mechanism and clinical treatment strategy ofCPE-induced inflammation.
Published Version
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