Evaluation of changes in choroidal thickness after implantable collamer lens surgery in high myopia patients with graves\u2019 Ophthalmopathy (inactive phase)

Fanglin He,Jing Zhang,Renbing Jia,Yan Liu

doi:10.1186/s12886-020-01612-9

Fanglin He, Jing Zhang + Show 2 more

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https://doi.org/10.1186/s12886-020-01612-9

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Journal: BMC ophthalmology	Publication Date: Aug 25, 2020
Citations: 1	License type: open-access

Affiliation: Shanghai Ninth People's Hospital

Abstract

BackgroundTo evaluate the safety and effectiveness of the Visian Implantable Collamer Lens (ICL) implantation in high myopic patients with inactive Graves’ ophthalmopathy (GO) by observing the changes of choroidal thickness (CT).MethodsEight patients (16 eyes) with high myopia accompanied with inactive GO were selected as the experimental group (group A) and 18 high myopic patients (36 eyes) without GO were selected as a control group (group B). The outcomes of uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BCVA), safety index, efficacy index, intraocular pressure (IOP), vault, corneal endothelial count, and choroidal thickness (CT) were observed. The values of CT were measured using swept-source optical coherence tomography (SS-OCT) scans.ResultsThe UCVA and BCVA in all operated eyes were better than that before surgery. The postoperative safety index and efficacy index were 1.23 and 1.19 in the group A, respectively, and 1.26 and 1.21 in the group B, respectively. In both groups, foveal CT increased significantly in high myopic patients at 2 h and at 3 months after surgery, compared to preoperative values. The same tendencies were observed in the inner nasal and outer nasal regions. Compared with patients without GO, the increase of CT was more obvious in GO patients, 2 h postoperatively (P = 0.006) and 3 months postoperatively (P = 0.011).ConclusionsThe ICL implantation is safe and effective in high myopic patients with inactive GO. Subfoveal and nasal CT may be useful parameters for monitoring the activity of GO patients.

Highlights

To evaluate the safety and effectiveness of the Visian Implantable Collamer Lens (ICL) implantation in high myopic patients with inactive Graves’ ophthalmopathy (GO) by observing the changes of choroidal thickness (CT)
Eight patients (16 eyes) with high myopia accompanied with inactive GO were selected as the experimental group and 18 high myopic patients (36 eyes) without GO were selected as a control group
The aim of this study was to evaluate the potential changes in the CT after ICL surgery, using the swept-source optical coherence tomography (SS-OCT) technique, and to determine whether the variations of the CT correlated with GO

Summary

Introduction

To evaluate the safety and effectiveness of the Visian Implantable Collamer Lens (ICL) implantation in high myopic patients with inactive Graves’ ophthalmopathy (GO) by observing the changes of choroidal thickness (CT). The Visian Implantable Collamer Lens (ICL; STAAR Surgical, Nidau, Switzerland), a posterior chamber phakic intraocular lens, is a precise, reproducible, and reversible technique for correcting refractive errors, and is especially suitable for some myopic patients with thin corneal thicknesses or corneal ectasia with limited ablation in corneal refractive surgeries. Graves’ Ophthalmopathy (GO) is an autoimmune inflammatory disorder. It is observed in approximately 25–50% of the patients with Graves’ disease (GD) and in 2% of the patients with thyroiditis.[1] The most common clinical features of these patients are upper eyelid retraction, edema, conjunctivae, and proptosis.[2] GO is the most commonly observed mild clinical form, the condition of approximately 3–5% of the patients with GO worsens and progresses toward the severe form. Considering these factors, ICL surgery may be a better option for myopia patients with GO

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