Abstract
The present study was designed to scientifically evaluate the cardio protective potential of Ethanolic Extract of dried leaves of Cinnamomum tamala (Family: Lauraceae) (EECT), against doxorubicin induced myocardial infarction in Wistar albino rats. Myocardial infarction was produced in rats with 15mg/kg of doxorubicin administered intraperitoneally (i.p), in six divided doses for two weeks. Effect of oral treatment of EECT at two doses (200 and 400 mg/kg body weight), both in prophylactically and curatively manner was evaluated against doxorubicin (15mg/kg,i.p) induced myocardial infarction. Levels of marker enzymes- Creatinine Phospho Kinase (CPK), Lactate Dehydrogenase (LDH), Alanine Amino Transferase(ALT) and Aspartate Amino Transferase(AST) were estimated in both the serum and heart tissues; antioxidant parameters viz., catalase (CAT) and malondialdehyde (MDA) were assayed in heart homogenate. Doxorubicin significantly increases the serum levels of marker enzymes and reduction of endogenous antioxidants when compared with normal rats. EECT elicited a significant cardio protective activity by lowering the levels of serum marker enzymes and lipid peroxidation and elevated the levels of catalase. The study confirms the cardioprotective potential of EECT against doxorubicin-induced cardiotoxicity in rats.
Highlights
Epidemiological studies predict an ominous prevalence of cardio vascular diseases globally as well as in India during decade
The antidiabetic activity, anti-bacterial activity, antioxidant activity, antimicrobial, antiinflammatory activity, anti-diarrhoeal activity and antihyperlipidemic activity of CT extracts have been evaluated. Based on this information present study was designed to investigate the cardioprotective effect of ethanolic extract of Cinnamomum tamala Nees. leaves.[5]
After complete extraction and drying, the dried mass of the different extracts of Cinnamomum tamala leaves was weighed in a digital balance
Summary
Epidemiological studies predict an ominous prevalence of cardio vascular diseases globally as well as in India during decade. The dried leaf of this plant is a spice commonly used in Indian homes for seasoning. It belongs to the family Lauraceae and is indigenous to the Asian minor and southern Europe.[4]. The antidiabetic activity, anti-bacterial activity, antioxidant activity, antimicrobial, antiinflammatory activity, anti-diarrhoeal activity and antihyperlipidemic activity of CT extracts have been evaluated. Based on this information present study was designed to investigate the cardioprotective effect of ethanolic extract of Cinnamomum tamala Nees. Based on this information present study was designed to investigate the cardioprotective effect of ethanolic extract of Cinnamomum tamala Nees. leaves.[5]
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