Abstract
The purpose of the study was to evaluate, cTnT as a sensitive and specific diagnostic and prognostic biomarker for myocardial damage among, CKMB and LDH in AMI cases by correlation analysis study.A 50 patients of both sex (36-70 yrs.), with symptoms of acute myocardial infarction within 6 hours of onset were included in the study. Cardiac specific Troponin T, CKMB and LDH were measured at the time of admission. Descriptive statistics and Pearson correlation analysis were done. A statistically highly significant positive correlation was found between cTnT and CKMB (r (48) = 0.708, and p 0.0001), between cTnT and LDH (r (48) = 0.740 and p 0.0001) and between CKMB and LDH (r (48) = 0.531 and p 0.0001.We conclude and further we support the fact that cTnT estimation is sufficient as a, specific and sensitive biomarker for AMI diagnosis and prognosis over CKMB and LDH isoenzymes.
Highlights
Myocardial infarction (MI) is a major cause of death and disability worldwide
CTnT is an independent prognostic marker which can predict the near, mid and even long term outcome of patients with acute coronary syndrome (ACS).(5) Low concentrations of Cardiac troponin T (cTnT) can be detected in clinically stable patients such as patients with ischemic or non-ischemic heart failure,(6) patients with different forms of cardiomyopathy,(7) renal failure,(8) and diabetes.[9]. Myocardial cell injury leading to elevated cTnT concentrations in the blood can occur in other clinical conditions such as myocarditis,(10) heart contusion,(11) pulmonary embolism[12] and drug-induced cardiotoxicity.[13]. Other diagnostic tests such as myoglobin, CK-MB, natriuretic peptide (NT-proBNP), placental growth factor (PlGF) and C-Reactive protein (CRP) can complement the diagnostic and prognostic information of cTnT in different indications.[14]
We evaluated whether cTnT estimation alone is satisfactory as biomarker for diagnosis and prognosis of Acute Myocardial Infarction (AMI) by doing correlation analysis study
Summary
Myocardial injury is detected when blood levels of sensitive and specific biomarkers such as cTn or the MB fraction of creatine kinase (CKMB) are increased.[1] Cardiac troponin T (cTnT) originating exclusively from the myocardium [cardiac TnT, molecular weight (39.7 kD)] clearly differs from skeletal muscle TnT. CTnT is an independent prognostic marker which can predict the near, mid and even long term outcome of patients with acute coronary syndrome (ACS).(5) Low concentrations of cTnT can be detected in clinically stable patients such as patients with ischemic or non-ischemic heart failure,(6) patients with different forms of cardiomyopathy,(7) renal failure,(8) and diabetes.[9] Myocardial cell injury leading to elevated cTnT concentrations in the blood can occur in other clinical conditions such as myocarditis,(10) heart contusion,(11) pulmonary embolism[12] and drug-induced cardiotoxicity.[13] Other diagnostic tests such as myoglobin, CK-MB, natriuretic peptide (NT-proBNP), placental growth factor (PlGF) and C-Reactive protein (CRP) can complement the diagnostic and prognostic information of cTnT in different indications.[14]. CK-MB 2 isoform greater than 1.0 U/liter or a ratio of CK-MB2 to CK-MB1 greater than 2.5 has sensitivity for diagnosing MI of 46.4% at 4 hours and of 91.5% at 6 hours
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