Abstract
Cancer drugs with pharmacological activity can be found in many different natural sources. Invitro and invivo research have shown that capsaicin incorporated chitosan nanoparticles (CAP@CS) have anticancer properties. CAP's medicinal potential is limited by its poor water solubility and bioavailability. This research presents the synthesis and characterization of CAP@CS nanoparticles encapsulated in a cellulose acetate membrane (CAP@CS/CA) for potential use in cancer therapy and the treatment of diabetes. The synthesized CAP@CS/CA membrane was analyzed using Scanning Electron Microscopy, Thermogravimetric analysis, mechanical strength testing, and drug release studies. Renal cell carcinoma (ACHN) cancer cell lines were used to test the efficacy of the synthesized CAP@CS/CA membrane in inhibiting tumor growth. These findings point to the synthesized CAP@CS/CA membrane as a potential new therapeutic agent for treating skin cancer and for its antibacterial properties. The capacity of the CAP@CS/CA membrane to inhibit carbohydrate digesting enzymes such a-amylase with IC50 values as low as 62.5 mg/mL−1 demonstrates its antidiabetic efficacy. We conclude that the CAP@CS/CA membrane has promising potential antidiabetic potential against important diabetes enzymes and is a perfect nanomedicine for nano-biomedical applications.
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