Abstract
Evaluation of Cancer Chemopreventive Potentials of Bixa orellana L. Leaf Extract
Highlights
Irrespective of data disparities in the exact incidence and prevalence of cancer, it is globally accepted that morbidity and mortality associated with cancer are on a steady increase.[1]
The main effective compound was thought to be Bixin. These activities and compounds have been greatly associated with the seed with little or no scientific studies on the cancer chemopreventive potentials of the leaf extract.[9]
This study evaluated the possible cancer chemopreventive mechanisms of Bixa orellana leaf extract and characterization of major phytoconstituents responsible for this activity
Summary
Irrespective of data disparities in the exact incidence and prevalence of cancer, it is globally accepted that morbidity and mortality associated with cancer are on a steady increase.[1]. Following a purported increased incidence of new cancer cases in Brazil, Bixa orellana was among the dietary plants proposed as a viable chemopreventive strategy for Brazilians.[8] Extract and compounds from B. orellana have been documented to possess anticancer/antitumor effects.[9] The main effective compound was thought to be Bixin These activities and compounds have been greatly associated with the seed with little or no scientific studies on the cancer chemopreventive potentials of the leaf extract.[9] A 6-month chronic toxicity study with the leaf extract in humans demonstrated no significant or obvious adverse effect.[10] This study evaluated the possible cancer chemopreventive mechanisms of Bixa orellana leaf extract and characterization of major phytoconstituents responsible for this activity
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