Abstract
Background: Myocardial infarction (MI) is one of the most common cardiovascular diseases. It accounts for about half of death cases in Iran. The objective of this study was to compare the activity of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) enzymes in serum and saliva of the MI patients compared to the healthy controls.
 Methods: Serum and salivary BChE and AChE levels were measured immediately following MI, and then 24 and 72 hours later. Four mL of blood and two mL saliva were collected for this purpose. These measurements were also collected in 30 healthy controls. The enzymes were assayed using spectrophotometry.
 Results: The activity of salivary AChE in the MI patients was lower than that of the healthy controls right after, 24 hours, and 72 hours following MI. However, serum AChE did not show a significant difference between the two groups. The activity of serum BChE in the MI patients was lower than that of the healthy controls right after, 24 hours, and 72 hours following MI. However, salivary BChE did not show a significant difference between the two groups.
 Conclusion: The activity of salivary AChE decreased in the MI patients compared to the healthy controls, which can be a marker to diagnose MI in the future.
Highlights
Myocardial infarction (MI) is the permanent and irreversible death of myocytes that is caused by ischemia induced by the blockage in the blood supply into the affected region 1
The serum levels have been shown based on sex which shows no significant difference in both male and female at the three time points, but there was a significant difference at each time compared to the controls
The salivary levels have been shown based on sex which shows no significant difference in both male and female at the three time points, but there was a significant difference at each time point compared to the controls
Summary
Myocardial infarction (MI) is the permanent and irreversible death of myocytes that is caused by ischemia induced by the blockage in the blood supply into the affected region 1. Acetylcholinesterase (AChE) enzyme activity in the serum and saliva is one of the factors that have been studied to diagnose MI. Myocardial infarction (MI) is one of the most common cardiovascular diseases. It accounts for about half of death cases in Iran. The objective of this study was to compare the activity of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) enzymes in serum and saliva of the MI patients compared to the healthy controls. Results: The activity of salivary AChE in the MI patients was lower than that of the healthy controls right after, 24 hours, and 72 hours following MI. The activity of serum BChE in the MI patients was lower than that of the healthy controls right after, 24 hours, and 72 hours following MI.
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