Abstract
This study investigated the burn healing efficiency of Black seeds (Nigella sativa L.) oil on the second degree burn wound models in rats. Many of pharmacological activities of Nigella sativa seeds such as anti-inflammatory and antioxidant were due to unsaturated fatty acids and essential oil [1,2,3]. In this study the hexanic extract of seeds was topically applied to evaluate the healing activity of seeds oil. Animals were randomly divided into three groups of six for each group. Burn wounds were created on dorsal part of shaved rats by a soldering iron with a flat contact surface (diameter 1.5cm) on top (100°C for 10 seconds). Silver sulfadiazine (SSD) was used as an antiseptic standard drug. Wound healing was evaluated by the rate of contraction and histological characteristics in treated and untreated groups. On day 12, the extract-treated animals showed 81.20% decreasing in the wound district and were significantly (P<0.05) more than control group 63.31%. Histological study showed fully grown regenerated epidermis on day 12 in treated animals. The results of this study suggest that burn wound healing potential of seeds may be due to anti-inflammatory, antioxidant and antimicrobial activities of main compounds oil.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
