Abstract
Introduction: Treatment of periodontal diseases done by surgical therapy depends upon extent and severity of disease. The ultimate goal of periodontal reconstructive surgery is to regenerate tissues destroyed during periodontal disease.
 Objective: To evaluate the effectiveness of bovine-derived xenograft with collagen membrane in treatment of intrabony defects by comparing it with open flap debridement alone.
 Methods: This non-randomised controlled trial was conducted after ethical clearance, at Bir hospital from 2018 March to 2019 April. The study recruited 38 patients by convenience sampling, age from 25-44 years, with chronic periodontitis, and willing to sign informed consent. Intrabony defects were treated by open flap debridement with bovine-derived xenograft and bioresorbable collagen membrane (Test group) and open flap debridement alone (Control group). Probing pocket depth, clinical attachment level, gingival recession, oral hygiene status, and gingival status were assessed at baseline and six months.
 Results: Six months after therapy, in Test group probing pocket depth reduction was 5.2 mm and gain in mean clinical attachment level was 4.3 mm. In Control group, mean probing pocket depth reduction was 3.8 mm and mean gain in clinical attachment level was 2.7 mm. The test treatment resulted in statistically higher probing pocket depth reduction and clinical attachment level gain than Control group.
 Conclusion: Both therapies resulted in significant probing pocket depth reductions and clinical attachment gains, and treatment with open flap debridement with bovine-derived xenografts and collagen membrane resulted in significantly higher probing pocket depth reduction and clinical attachment gain than treatment with open flap debridement alone.
Highlights
Treatment of periodontal diseases done by surgical therapy depends upon extent and severity of disease
The results of this study indicated that surgical therapy in open flap debridement alone and OFD with bovine-derived xenograft along with collagen membrane led to a clinically significant probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain in patients with chronic periodontitis but statistically significant only in case of CAL at six months across both groups
Mean value of difference between the clinical parameters as PPD and CAL at baseline and six months showed statistically significant difference which helps in drawing the inference that Intrabony Defect (IBD) treated with OFD along with Bovine-derived xenograft (BDX)+collagen membrane (CM) have improved healing compared to OFD alone
Summary
Treatment of periodontal diseases done by surgical therapy depends upon extent and severity of disease. Surgical periodontal therapy with use of bone grafts along with. Gorkhali RS, Pradhan S, Shrestha R, Agrawal S, Lamicchane K, Koirala PK, et al Evaluation of Bovine-derived Xenograft Combined with Bioresorbable Collagen Membrane in Treatment of Intrabony Defects. Guided tissue regeneration (GTR) is more effective than an open flap debridement (OFD) alone.[2] Membrane placement is based on biological principles of GTR which prevents apical migration of gingival epithelial cells during initial stages of healing allowing periodontal ligament cells to repopulate root surface.[3] GTR is combined with bone grafts to support barrier material and to prevent it from collapsing into defect or onto root. Bovine-derived xenograft (BDX) which possesses good osteoconductive properties has been introduced as a grafting material for regenerative periodontal surgery.[5,6]
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