Evaluation of Biochemical and Hematological Dynamics as Markers for Severe Dengue Forms

Abstract

Dengue is a viral infection that has become a serious problem in recent years. It is a major cause of mortality and morbidity. The present study is a prospective, hospital-based, observational study done from 2015 to October 2022. The objective of our study was to consider whether dengue infection can be suspected based on hematological and biochemical findings. The study included 100 patients positive for dengue infection. Complete haemograms, transaminases for liver injury, blood urea, and serum creatinine levels for renal assessment were performed for these patients. The most common hematological findings were thrombocytopenia, leucopenia, an increase in the mixed cell fraction of the leucocytes, and the presence of reactive lymphocytes. Biochemical parameters like aminotransferases, blood urea, and serum creatinine levels were significantly raised. Hence, a platelet count of <100,000 cells/μl, leucopenia of < 4000 cells/μl, and aspartate aminotransferase levels of >82.2 U/L can be considered predictors of dengue infection