Evaluation of beta-adrenergic influences on cardiovascular and metabolic adjustments to physical and psychological stress.

Abstract

ABSTRACTThis study was designed to examine the hypothesis that certain behavioral demands may tend to trigger sympathetic mechanisms which result in metabolically excessive cardiac output elevations. Oxygen consumption and cardiac output adjustments during a contrived reaction‐time shock‐avoidance task were compared to a cold pressor test in healthy young male adults. The linear cardiac output/oxygen consumption relationship generated by performance on a graded exercise task was used to assess the metabolic appropriateness of cardiac output adjustments to the reaction‐time task and cold pressor. The reaction‐time task was generally found to evoke metabolically excessive increases in cardiac output, while cardiac output adjustments to cold pressor were more consistent with changes in metabolic demands. However, the tasks were associated with similar heart rate responses, with a significant attenuation in stroke volume during cold pressor accounting for the differential alterations in cardiac output. This finding suggests a limited reliability for heart rate as an index of cardiac performance. The effects of propranolol, which was employed to evaluate the role of sympathetic influences, indicated that beta‐adrenergic mechanisms were responsible for mediating the cardiac output response to the reaction‐time task, but only partially contributed to the cold pressor response. Post‐hoc analyses of individual differences in cardiovascular reactivity to the reaction‐time task suggest that, for hyperreactive individuals, the coping responses evoked by this task may lead to tissue overperfusion with oxygen, thereby providing a stimulus for autoregulatory vascular reflexes which may be associated with the etiology of hypertensive disease.