Abstract

Evaluation Of Bcl-2 Gene Translocation In NSCLC Lung Cancer Based On Age And Sex Seg

Highlights

  • All excised slides were examined by a pathologist using a light microscope and Non-small cell lung carcinoma (NSCLC) lung cancer specimens were confirmed by a pathologist at this stage

  • The positive mcr samples were banded on 1% agarose at 630 bp region and the icr positive samples were banded on 1% agarose at 135 bp region

  • Because the incidence of NSCLC is directly related to age, the incidence of cancer increases with increasing age of the population

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Summary

Introduction

The cause of most cancers is the accumulation of mutations in somatic cells. Cell death has a genetic basis and does not occur if this genetic system is disrupted [1].Cell death is part of the growth program in animal cells. The cause of most cancers is the accumulation of mutations in somatic cells. Cell death has a genetic basis and does not occur if this genetic system is disrupted [1]. Cell death is part of the growth program in animal cells. Planned cell death (apoptosis) is important to avoid cancer. All the protein’s family found in B-cell lymphoma has a common similar region called the second Bcl-2 identical. These regions are involved in regulating the release of cytochrome C from mitochondria. Cytochrome C release is a common event in apoptosis. Cytosolic cytochrome C with binding to apoptotic factors such as Factor-1 (Apaf-1, Apoptotic protease activating factor 1), dATP/ ATP and procaspase 9 makes the complex of apoptosomes [2]

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