Evaluation of autologous and homologous platelet rich plasma as a surgical wound healing promoter in rabbits

Abstract

The present study compared the efficacy of autologous and homologous platelet rich plasma (PRP) as a surgical wound healing promoter in rabbits. Sixteen adult healthy rabbits were divided into two groups i.e. A and B. Group A was treated with autologous platelet rich plasma (APRP) and group B was treated with homologous platelet rich plasma (HPRP). Both groups were operated for skin grafting (auto grafting) at two (PRP treated experimental and control) sites. Clinical evaluation of PRP was performed by using macroscopic (edema, exudation, coloration, temperature, cosmetic appearance and healing status) and microscopic (acute inflammation, fibroblast proliferation and granulation tissue proliferation) parameters. The healing status, coloration and cosmetic appearance of APRP treated group were more satisfactory than HPRP treated group. APRP group also showed less inflammation, edema and more granular tissue proliferation as compare to HPRP group. It was concluded that autologous PRP is an efficient surgical wound healing promoter in rabbits.