Effects of Autologous and Homologous Platelet Rich Plasma on Full Thickness Autologous Skin Graft in Dogs

Abstract

Background: Wound healing is a complicated mechanism that includes inflammatory, proliferative and remodelling stages. Platelet rich plasma (PRP) is a small volume of blood plasma fortified with platelets and growth factors that enhance the healing by stimulating angiogenesis and formation of granulation tissue. Methods: The present study was performed to evaluate the effect of autologous and homologous platelet rich plasma on full thickness dermatological reconstructive surgery in dogs. The dogs were divided in two groups A and B, each with four clinical cases. In groups A and B, autologous and homologous PRP was used respectively as skin graft augmentation. The macroscopic parameters of the study included colour, edema, exudation and histopathological parameters included acute inflammation, fibroblast proliferation and granulation tissue formation. All these observations were made on days 3, 7 and 14 post-operatively. Result: On the basis of findings of this study, it was concluded that autologous PRP is a better graft healing promoter in terms of self-limiting acute inflammation, fibroblast proliferation, granular tissue and early healing of graft as compared to homologous PRP.