Abstract
Objectives: The purpose of the present study was aimed at evaluating the antipyretic and antiulcer activity on leaves of Trema orientalis L. (family Cannabaceae) on albino Wistar rats. The antipyretic and antiulcer activity of the ethanolic extract of the T. orientalis L. leaves in three different concentrations (100, 200, and 300 mg/kg) was compared with standard paracetamol and pantoprazole, which was evaluated by employing Brewer’s yeast-induced pyrexia and ethanol-induced ulcer model. The biochemical parameters such as the volume of gastric juice secretion, pH, total acidity, ulcer index, percentage protection, and lipid peroxidation were also studied.
 Methods: T. orientalis leaves were extracted with ethanol by the Soxhlet extraction method. The dried extract was used for further phytochemical and pharmacological analysis. The antipyretic effect was studied using Brewer’s yeast-induced pyrexia. The ethanol-induced ulcer model was used to study the antiulcer effect.
 Results: The percentage yield of ethanolic extract of T. orientalis leaves was found to be 6.71% w/w, respectively. The extract showed significant antipyretic and antiulcer effect when compared with standard paracetamol and pantoprazole.
 Conclusion: The ethanolic extract of T. orientalis has significant antipyretic and antiulcer action.
Highlights
Peptic ulcer The peptic ulcer is characterized by an area of the gastrointestinal tract (GIT) which has been damaged by gastric acid or pepsin
OCP/Institutional Animal Ethics Committee (IAEC)/2018-19/02 conducted acute oral toxicity study prescribed by the OECD guideline 423 and the results suggested that there were no toxic signs observed in clinical parameters during acute toxicity study up to 2000 mg/kg
The results of the present study suggest that the ethanol extract of T. orientalis leaves may be beneficial in the treatment of gastric ulcer induced by aggressive factors
Summary
Peptic ulcer The peptic ulcer is characterized by an area of the gastrointestinal tract (GIT) which has been damaged by gastric acid or pepsin. The peptic ulcer is characterized by an area of the GIT which has been damaged by gastric acid or pepsin. A peptic ulcer can refer to gastric ulcer, duodenal ulcer, or esophageal ulcer [1]. Peptic ulcer is one of the major gastrointestinal disorders and it affecting about 10% of the world population. About 15000 deaths occur every year due to the consequences of peptic ulcer [2]
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