Abstract
Objective: The purpose of the present study was aimed at evaluating the antipyretic and antiulcer activity on leaves of Alstonia scholaris L. (Family Apocynaceae) on albino Wistar rats. The antipyretic and antiulcer activity of the ethanolic extract of the A. scholaris L. leaves in three different concentrations (50, 100, and 200 mg/kg) were compared with standard paracetamol and pantoprazole, which was evaluated by employing brewer’s yeast-induced pyrexia and ethanol-induced ulcer model. The biochemical parameters such as the volume of gastric juice secretion, pH, total acidity, ulcer index, percentage protection, and lipid peroxidation (LPO) were also studied.
 Methods: A. scholaris leaves were extracted with ethanol by Soxhlet extraction method. The dried extract was used for further phytochemical and pharmacological analysis. The antipyretic effect was studied using brewer’s yeast-induced pyrexia. The ethanol-induced ulcer model was used to study the antiulcer effect.
 Results: The percentage yield of ethanolic extract of A. scholaris leaves was 15.81%w/w, respectively. The extract showed significant antipyretic and antiulcer effects when compared with standard paracetamol and pantoprazole.
 Conclusion: The ethanolic extract of A. scholaris has significant antipyretic and antiulcer activity.
Highlights
Peptic ulcers are one of the most common gastrointestinal diseases and widespread global problem in modern era arise due to various factors [1,2]
The antiulcer property of A. scholaris in ethanol-induced ulcer model is evident from its significant reduction in total acidity, gastric volume, pH, lipid peroxidation (LPO), number of ulcers, and ulcer index (UI)
The results of the present study suggest that the methanol extract of A. scholaris leaves may be beneficial in the treatment of gastric ulcer induced by aggressive factors
Summary
Peptic ulcers are one of the most common gastrointestinal diseases and widespread global problem in modern era arise due to various factors [1,2]. The exploding occurrence of peptic ulcer in the first half of 20th century in the medical scene led to recommend it as an epidemiological illness, which was followed by a reducing range of incidence and vanished as a surgical medicinal condition. The reason for this decline is due to more effective acid suppression drugs such as H2 receptor blockers, proton pump inhibitor, and recognition of Helicobacter pylori [6]
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