Abstract
The mollusk <em>Cyclina sinensis</em> has been widely used as a food and folk medicine in China, Korea and south eastern Asia. In this study, Total Water-soluble Extracts (TWE), Crude Polysaccharides (CPS), Total Crude Proteins (TCP) were isolated from <em>C. sinensis</em> and the Deproteinized Polysaccharides (DPS) was obtained after deproteination of CPS. Their contents, such as neutral carbohydrate, protein and uronic acid, were measured. Their antioxidative properties against 1, 1'-Diphenyl-2-Picrylhydrazyl (DPPH) free radical, hydroxyl free radical and superoxide anion free radical, as well as their reducing capacity were investigated. Results showed that various fractions of <em>C. sinensis</em> can scavenge all free radicals tested above and possessed the increasing reducing capacity in a dose-dependent mode. Compared with the other three fractions, TWE represents the comprehensively best antioxidative properties. The antioxidative activities of TWE from <em>C. sinensis</em> might contribute to antioxidant-related functional food and pharmaceutical industries.
Highlights
The free radicals are derived from by-products of biological reactions or exogenous factors and can cause oxidative damages related to aging and many diseases, such as cancer, atherosclerosis and Alzheimer's disease (Duan and Kasper, 2011)
Total Water-soluble Extracts (TWE), Crude Polysaccharides (CPS) and Deproteinized Polysaccharides (DPS) possess comparative activities of scavenging the DPPH radical compared with Ascorbic Acid (AA) except Total Crude Proteins (TCP)
The results suggested that TWE, CPS and DPS have significantly DPPH radical scavenging effect
Summary
The free radicals are derived from by-products of biological reactions or exogenous factors and can cause oxidative damages related to aging and many diseases, such as cancer, atherosclerosis and Alzheimer's disease (Duan and Kasper, 2011). It has been found that the synthetic antioxidants may cause many toxic effects (Guo et al, 2013). Known as Chinese venus, iron clam and black clam, is a bivalve mollusk belonging to Veneridae (Wang et al, 2006). It is widely distributed along the coastal of China, Korea and south eastern Asia and one of the commonly bivalve species in Chinese aquaculture (Liu et al, 2002). There were reported that the extraction and bioactivities such as anti-tumor, antioxidant of polysaccharides from C. sinesis (Jiang et al, 2011; Guo et al, 2013). To the best of our knowledge, there were no reports of systematic studies of antioxidant fractions of C. sinesis
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