Abstract
Cellular oxidative stress is the leading cause of the worst outcome of myocardial infarction (MI) in diabetes. Diabetes Mellitus is one of the important risk factors for heart pathology, because of increased production of Reactive oxygen Species(ROS).The present study was designed to find out the antioxidant status in diabetic and non-diabetic MI Patients.100 MI patients were grouped into 50 Diabetic MI(group 2) and 50 Non diabetic MI(group 3) and was compared with age matched 50 controls (group1). Malondialdehyde(MDA) or Thiobarbituric acid reactive substances (TBARs), antioxidant enzymes Superoxide Dismutase(SOD) &Catalase were measured in erythrocytes and Vitamin C in plasma was measured. The result showed that there is a significant decrease in the antioxidant status in diabetic and non-diabetic MI patients and a simultaneous significant increase in the lipid peroxidation .Thus there is an imbalance between oxidant and antioxidant molecules in MI patients, and magnitude of imbalance is greater in diabetic MI patients, possibly because of greater oxidative stress in diabetic patients. Potentially antioxidant therapy may play a critical role in reducing morbidity and mortality in MI.
Highlights
Acute myocardial infarction (MI) is defined as death or necrosis of myocardial cells
Both the patient groups showed significant decrease in the vitamin C levels when compared to the control(Figure :1)
The sources of variation for multiple comparisons were assessed by analysis of variance(ANOVA), followed by Post Hoc test with Bonferroni’s multiple comparisons test for Superoxide dismutase (SOD), CAT, Vitamin C but one variable,Thiobarbituric acid reactive substances (TBARs) was assessed by Kruskal – Wallis test, followed by Mann-Whitney U test
Summary
Acute myocardial infarction (MI) is defined as death or necrosis of myocardial cells. Diabetes increases the risk of MI because it increases the rate of atherosclerotic progression and adversely affects blood cholesterol levels. This accelerated form of atherosclerosis occurs regardless of whether a patient has insulin-dependent or noninsulin-dependent diabetes. Diabetes mellitus act as a source of vascular dysfunction through the formation of REACTIVE OXYGEN SPECIES and increase the risk of Oxidative stress is caused by an imbalance between the production of reactive oxygen Species and a biological system's ability to readily detoxify the reactive Oxygen Species or repair the resulting damage. Reactive oxygen species (ROS) include oxygen ions, free radicals and peroxides both inorganic and organic They are generally very small molecules and are highly reactive due to the presence of unpaired valence shell electrons. Inhibition of the antioxidant enzymes causes oxidative stress and may damage or kill cells
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