Abstract
The present study aimed to determine the antibacterial, antioxidant, cytotoxic activities and element levels of Verbascum lasianthum Boiss. ex Bentham. The free radical scavenging activity, total phenolic content, total antioxidant capacity, total oxidant capacity levels were analyzed as the antioxidant parameters. Seven bacteria and one yeast strains were used to determine the antimicrobial activity. The cytotoxic effects of plant extracts were determined using A549, MCF-7, HepG2 and SH-SY5Y cell lines. The findings demonstrated that the antioxidant activity increased with an increase in the phenolic content of extracts. This species is rich in bio-elements such as Fe, Cu, Mn, Zn, and Mg. Different concentrations of extracts could have antibacterial activity. This plant had an apparent cytotoxic effect only in the A549 cell line and increased the proliferation in other cell lines. The findings demonstrated that plant could be used alone or as a supplement to the current treatment protocols in diseases due to their antioxidant, antibacterial and cytotoxic effects. However, it is recommended that Verbascum L. species intended for use in therapy should be procured from areas where there is no soil pollution or organic farming is preferred.
Highlights
Verbascum L. (Scrophulariaceae) species, known as verbasco, are frequently used in several countries due to its mucolytic effects, in relieving the upper respiratory tract
Antibacterial, antioxidant, cytotoxic effects and element levels of Verbascum lasianthum Boiss. ex Bentham species was investigated in the present study
Verbascum lasianthum was investigated in terms of biological activity and element content in the present study
Summary
Verbascum L. (Scrophulariaceae) species, known as verbasco, are frequently used in several countries due to its mucolytic effects, in relieving the upper respiratory tract. Different Verbascum species are used in the treatment of wounds, eczemas, hemorrhoids, and diarrhea in traditional medicine in different regions (Akdemir et al 2011, Alipieva et al 2014, Suntar et al 2010, Kahraman et al 2010). Dried Verbascum L. leaves and flowers, oil extracts, alcoholic tinctures, capsules are sold as alternative medicine products in pharmacies and markets in most countries (Luca et al 2019). There are about 360 types of Verbascum species globally and Turkey is the country with the most diversity (Bani et al 2010). Verbascum lasianthum is a biennial herb widely grown in Turkey. Like many other Verbascum species, it is used for its mucolytic effects. Antibacterial, antioxidant, cytotoxic effects and element levels of Verbascum lasianthum Boiss. Antibacterial, antioxidant, cytotoxic effects and element levels of Verbascum lasianthum Boiss. ex Bentham species was investigated in the present study
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