Abstract
Aims: Aim of present study was to investigate the protective eff ect of Acacia modesta bark (Am. Cr) and its proposed mechanism against Paracetamol - induced hepatotoxicity in mice. Study Design : Albino mice (20 - 30 g) of either sex were divided into five groups with six animals in each. Group - I was considered as – ve contro l (recei ved normal saline), Group - II as + ve control (received paracetamol), while Group - III, IV and V as trail (received crud extract of A. modesta bark 12.5, 25 and 50 mg/ kg respectively). Blood samples were collected by cardiac puncture for analysis of different markers of hepatotoxicity. Place and Duration of Study: Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan, between April 2013 and 0ctober 2013. Methodology: Hepatotoxicity was assessed by evaluation of serum levels of hepatic metabo lic enzymes; alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and metabolic content; Bilirubin and level of plasma proteins synthesize by liver (albumin and globulin), by using Randox Test Kits and biochemical an alyzer Microlab 300
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