Abstract
The antioxidant and hepatoprotective activities of the extract of Moringa oleifera leaves were investigated against CCl4-induced hepatotoxicity in rats. Hepatotoxic rats were treated with ethanol extract of Moringa oleifera for a period of 60 days at the following three dose levels; 100, 200 and 400 mg/kg body weight/day, orally. The activities were studied by assaying the serum marker enzymes like SGOT, SGPT, GGT, LDH, ALP, ACP, as well as total bilirubin, total protein and albumin in serum concomitantly with the activities of LPO, SOD, CAT, GSH, GR and GPx in liver. The activities of all parameters registered a significant (p ≤ 0.001) alteration in CCl4 treated rats, which were significantly recovered towards an almost normal level in rats co-administered with M. oleifera extract in a dose-dependent manner. All the biochemical investigations were confirmed by the histopathological observations and compared with the standard drug. silymarin. Results suggest that the antioxidant and hepatoprotective activities of M. oleifera leaves are possibly related to the free radical scavenging activity which might be due to the presence of total phenolics and flavonoids in the extract and/or the purified compounds β-sitosterol, quercetin and kaempferol, which were isolated from the ethanol extract of M. oleifera leaves.
Highlights
Moringa oleifera Lam. is a drumstick tree of the Moringaceae family, known as sahinjan in Hindi.It is a native of India and grown extensively in many southeastern Asian countries in Thailand, Philippines and Pakistan etc. [1]
CCl4-intoxication to rats for the period of 60 days resulted in a significant (p ≤ 0.001) rise in the levels of SGOT, SGPT, GGT, LDH, ALP, ACP and total bilirubin along with notable reduction (p ≤ 0.01) in the levels of total protein and albumin in serum when compared with normal controls (Figures 4–7)
The effect of M. oleifera leaves extract on serum—SGOT, SGPT, GGT, LDH, ALP, ACP and total bilirubin in CCl4-induced rats—was found to be reduced significantly (p ≤ 0.001) along with remarkable elevation in the total protein and albumin at all three dose levels (Group III–V) as compared to CCl4-treated Group II
Summary
Moringa oleifera Lam. is a drumstick tree of the Moringaceae family, known as sahinjan in Hindi.It is a native of India and grown extensively in many southeastern Asian countries in Thailand, Philippines and Pakistan etc. [1]. Moringa oleifera Lam. is a drumstick tree of the Moringaceae family, known as sahinjan in Hindi It is a native of India and grown extensively in many southeastern Asian countries in Thailand, Philippines and Pakistan etc. The shade dried leaves of Moringa oleifera are widely utilized in developing countries as a good source of protein, calcium, vitamin A, C and E, β-carotene, amino acids, various polyphenolics and some natural anti-oxidizing agents [3]. It is used as an alternative source of nutritional supplements and growth promoters in various countries [4]
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