Abstract
In this study, we aimed to observe the cytotoxicity, antioxidant and anti-inflammatory activity of Rhododendron brachycarpum extract (RbE) in RAW 264.7 macrophage cell in vitro and the anti-inflammatory or soothing effect of RbE formulated cream (Multicalm-RHTM) on experimentally induced acute irritated skin in healthy subjects in vivo. In vitro study revealed that RbE significantly inhibited NO and ROS generation in a dose dependent manner without cytotoxicity. In clinical test, Multicalm-RHTM cream siginificantly reduced the SLS-enduced erythema after D5 compared to that of placebo. Overall, it can be concluded that the RbE is a non-cytotoxic, antioxidant and anti-irritant agent which can be used as a potent functional ingredient in cosmetics. Likewise, the in vivo clinical study shows that Multicalm-RHTM cream which contains 3% RbE can be used as an effective skin soothing agent.
Highlights
Envionmental exposure (UV radiation, pollutions, toxic chemicals and other hazardous agents) causes contact dermitites, halogen acne, chemical depigmentation, skin cancer and other acute and chronic skin damages [1].How to cite this paper: Ghimeray, A.K., Lee, H.Y., Kim, Y.H., Ryu, E.K. and Chang, M.S. (2015) Evaluation of Antioxidant and Anti-Inflammatory Effect of Rhododendron brachycarpum Extract Used in Skin Care Product by in Vitro and in Vivo Test
These results suggested that the inhibition of reactive oxygen species (ROS) and NO production by Rhododendron brachycarpum extract (RbE) might be managed by radical scavenging activity
RbE inhibits LPS-induced NO production in dose-dependent manner
Summary
Envionmental exposure (UV radiation, pollutions, toxic chemicals and other hazardous agents) causes contact dermitites, halogen acne, chemical depigmentation, skin cancer and other acute and chronic skin damages [1].How to cite this paper: Ghimeray, A.K., Lee, H.Y., Kim, Y.H., Ryu, E.K. and Chang, M.S. (2015) Evaluation of Antioxidant and Anti-Inflammatory Effect of Rhododendron brachycarpum Extract Used in Skin Care Product by in Vitro and in Vivo Test. Envionmental exposure (UV radiation, pollutions, toxic chemicals and other hazardous agents) causes contact dermitites, halogen acne, chemical depigmentation, skin cancer and other acute and chronic skin damages [1]. (2015) Evaluation of Antioxidant and Anti-Inflammatory Effect of Rhododendron brachycarpum Extract Used in Skin Care Product by in Vitro and in Vivo Test. To overcome this problem, the cosmetic industries and academic researchers have devoted much research toward the developement of various nautral skin care product from plant parts. Phytochemicals (secondary metabolites) from the plants are characterized for having antioxidant, anti-inflammatory, anti-carcenogenic, anti-aging and anti-bacterail properties [2]. The effective plants antioxidant compounds such as tocopherols, flavonoids, phenolic acids, alkaloids, monoterpenes are widely used in cosmetic products to protect the skin from environmental damages [3]
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