Coffee pulp supplement affects antioxidant status and favors anti-aging of skin in healthy subjects.

Abstract

Coffee and coffee products are known potentially to reduce levels of oxidative stress biomarkers in humans. This investigation evaluates the effects of coffee pulp extract as a functional supplement (in coffee pulp drink, CPD) and a cosmetic ingredient (coffee pulp serum, CPS). The effects of CPD and CPS for anti-oxidation and anti-aging were investigated. Forty subjects were randomly allocated to CPD or placebo drink groups (50ml of a CPD/placebo drink daily for 8weeks for each subject), and another 40 subjects were recruited to CPS or placebo serum groups (about 3ml of a CPS/placebo serum day and night/daily for 4weeks for each subject) in a double-blind study. The CPD and CPS (20%) can increase free radical scavenging activities by 93.3% and 85% (p<0.001) for DPPH, 94.5% and 61.3% (p<0.01) for ABTS·+ , 43.8% and 15.3% (p<0.05) for NO· than placebo. The inhibition of tyrosinase activity was increased by 91.6% and 51.0% (p<0.05) after CPD and CPS application. The CPD comprehensively improved the moisture, brightness, elasticity, spotting, texture, and collagen content of skin for most subjects after 8weeks, relative to the baseline without treatment (p<0.05). After 4weeks of CPS serum consumption, the brightness, elasticity, spotting, UV spots, and collagen content of skin were slightly better than those at week 0 (p<0.05). The daily consumption of coffee pulp extract products can slow the skin aging process and improve skin health.