Abstract
Introduction and Aim: The green-synthesized Manganese nanoparticles (MnNPs) were produced rapidly by treating Manganese ions with an aqueous extract of Hopea ponga leaf. The reaction process was monitored using UV-visible spectroscopy. FTIR spectra of plant extract and MnNPs are illustrated. The aim of the present study is to evaluate in-vitro antioxidant and anticancer activity of aqueous leaf extract of H. ponga and its synthesized MnNPs.
 Materials and Methods: Herbal extraction was carried out by Soxhlet extraction method with water as a solvent. The antioxidant potential of plant extracts and MnNPs were evaluated by FRAP, H2O2, DPPH and PM assays. The effect of aqueous extract of H. ponga along with its synthesized MnNPs on the viability of non- small cell lung cancer (A549) cells was determined by MTT assay.
 Results: The synthesized MnNPs showed significant antioxidant activity in all performed assays. The aqueous extract from leaves of H. ponga has strong dose dependent anticancer activity against non-small cell lung cancer cells A549.
 Conclusion: The newly synthesized MnNPs showed significant antioxidant activity in all performed assays. Further, aqueous extract from leaves of H. ponga have a strong dose dependent anticancer activity against non- small cell lung cancer cells A549.
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