Abstract
Abstract
 The increasing prevalence of antibiotic-resistant bacteria has emerged as a critical global public health issue, necessitating the exploration of alternative measures to combat infectious diseases. Traditional medicinal plants have been long recognized for their potential in providing natural compounds with antimicrobial properties for various therapeutic purposes. The diverse plant biodiversity in Turkey offers a promising potential for the discovery of novel antimicrobial compounds. Therefore, this study aimed to investigate the antimicrobial activities of methanolic extracts from several endemic and non-endemic plant species against various microorganisms. The endemic species included Verbascum lydium Boiss. var. lydium (stem), Euphorbia anacampseros var. tmolea Boiss. (root), Stachys tmolea subsp. tmolea Boiss. (leaves and stem), Rosa pisiformis subsp. pisiformis (fruit, petiole, root, leaves), while non-endemic species were represented by cultivated Aronia melanocarpa (fruit). In this research, the effectiveness of V. lydium, E. anacampseras, R. pisiformis (all tested parts) and A. melanocarpa (fruits) were demonstrated against Staphylococcus aureus and Escherichia coli. Methanolic extracts of the roots and leaves of R. pisiformis showed the most promising bioactivity with a MIC value of 62.5 µg mL-1 on Pseudomonas aeruginosa among all tested extracts. In addition, the results showed that antimicrobial bioactivities were observed for Candida parapsilosis, C. glabrata and Klebsiella pneumoniae for V. lydium; S. tmolea and R. pisiformis with MIC values of 31.5 µg mL-1 per each. The findings of this study could provide valuable information for future research into the use of Turkish plants for pharmacological purposes, public health and traditional medicine applications.
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