Evaluation of Antifungal Potential and Gastroprotective Effect of Ethanol Seed Extract of Spathodea Campanulata of Indomethacin Induced Gastric Ulcer, A Possible Application for Veterinary Animal

Abstract

The present study evaluates the effects of the plant seed extract of Spathodea Campanulata administration on microbial (Aspergillus niger, Aspergillus flavin, Candida tropicalis and Fusarium oxysporium.) and ulcer inhibition on common Veterinary Albino rats.Spathodea campanulata is an African plant which is used in tropical and subtropical areas for ornamental purposes as well as for the treatment of a range of diseases such as wounds, skin rashes, and haemorrhoids. Materials and Methods: Indomethacin for gastric-ulcer induction, Omeprazole and Tetracycline as standard drug, Disc diffusion method for antifungal and Histopathology for ulcer index. Results: The effects of ethanol seeds extract were studied for antifungal and antiulcer. Where a significant activity observed in various concentration on different fungi indicating a positive agent for the selected pathogens. Also, with 40 albino rats over a period of 7 days, the rats were divided into five groups, those in group one served as the control, group two as the negative control (Indomethacin), group three as the positive control (Omeprazole) and group four and five are dosed ranged groups from 200-400mg/kg extract. Tissue injury and its infiltration were examined and scored; the length and breadth of the lesion were measured for ulcer index. Inflammatory and fibrosis alteration were present in ulcer treated rats, at days 7 colonic wall thickening and fibrotic remodelling were evident as well as blood vessels remodelling. The percentage rate of healing was 10.03% at 200 ppm and 25.51% at 500ppm. The present findings provide an integrated view of ulcer healing processes occurring in the ulcer induced colonic compartment of rats induced by indomethacin. Conclusion: These ulcerogenic alterations may represent a suitable basis for understanding the effects of Spathodea campanulata ethanol seeds extract to ulcer treatment as well as an antifungal.