Evaluation of Antidiabetic Activity From the Root Extracts of Pavonia Odorata Wild in Alloxan Induced Diabetic Rates

Abstract

Pavonia odorata wild belongs to the family Malvaceae. It is a herb. Its roots have musk like aromatic odour. The roots yield an essential oil that contains isovaleric acid, isovaleraldehyde, aromadendrene, pavonene, a-terpinene, azulene and pavonenol. The roots are aromatic, and possess refrigerant, antipyretic, stomachic and astringent properties. Based on ethno pharmacological information , Pavonia Odorata Wild has been used to treat diabetes by the tribals in and around tropical and subtropical areas. But there are no more scientific reports available about the antidiabetic activity of this plant. Hence the study was carried out to ascertain the activity. The toxic effect of MeOH extract of Pavonia odorata root was studied at a dose level up to 2000 mg/kg b.w. The plant extracts were also evaluated for antidiabetic activity at a dose levels of 100 mg/kg of CHCl3 , 100 mg/kg of EtOAc and 200 mg/kg of MeOH in Alloxan induced diabetic rats. The plant extracts have not produced any toxic symptoms within the treated animals. In the high light of the results, our study indicates that Pavonia odorata root extracts have antidiabetic activity.The lowest blood glucose(157.00±4.36) levels was observed at 15 th day after oral administration of 100 mg/kg of CHCl3 extract of Pavonia odorata root .From the observations, it was concluded that the reduction of blood glucose levels in diabetic rats were found to be dose dependent and also dependent on duration of action. So it might be useful in the treatment of diabetes without toxicity.