Antidiabetic effect of matured fruits of Diospyros peregrina in alloxan-induced diabetic rats

Abstract

Th e methanol extract of matured fruits of Diospyros peregrina was evaluated for its antidiabetic activity in alloxan-induced diabetic rats. It was also intended to establish correlation with reduction of oxidative state associated with diabetes. Diabetes was induced by a single intraperitoneal injection of alloxan monohydrate (150 mg/kg body weight). Methanol extract was administered orally at doses of 150 and 300 mg/kg body weight for 14 consecutive days in diabetic rats. Fasting blood glucose level, serum lipid profi les, iver glycogen level, pancreatic thiobarbituric acid reactive substances (TBARS) as well initial and fi nal changes in body weight were evaluated. Experimental fi ndings showed signifi cant antidiabetic potential of extract in terms of reduction of fasting blood glucose level in diabetic rats. Observed data was found statistically signifi cant in reduction of serum lipid and pancreatic TBARS levels whilst signifi cant improvement was observed in liver glycogen level and body weight profi les in extract-treated diabetic rats. Th e eff ect of the extract particularly at 300 mg/kg was comparable to that of standard drug glibenclamide (1 mg/kg body weight). Key words: Alloxan, antihyperglycemic, diabetes, Diospyros peregrina, glibenclamide