Evaluation of Antibacterial, Antioxidant and Immunomodulatory Potential of Mitragyna parvifolia Leaves-Assisted Fe2O3 Nanoparticles

Abstract

This work includes the use of leaves of Mitragyna parvifolia for green synthesis of [Formula: see text] nanoparticles ([Formula: see text] NPs), which offers a sustainable eco-friendly approach. Characterization of synthesized [Formula: see text] NPs was done by UV-visible, FTIR spectroscopy, XRD and FESEM studies. FTIR exhibited the existence of Fe-O, O–H and COO–Fe stretching owing to the occurrence of the carboxylic group. FESEM analysis revealed that the average size of [Formula: see text] NPs was 92 nm, which varies in their shape. The study also includes the determination of antibacterial, in vitro antioxidant and immunomodulatory efficacy of synthesized [Formula: see text] NPs. Results suggested that [Formula: see text] NPs exhibit potent antibacterial efficacy against B. subtilis and S. aureus, gram-positive as well as E. coli and P. aureginosa, gram-negative bacterial strains used in this study. The study exhibited significant ([Formula: see text] < 0.01) in vitro antioxidant and immunomodulatory potential of synthesized [Formula: see text] NPs against concanavalin-A activated Wistar albino rat’s splenocytes. The green synthesized [Formula: see text] NPs using M. parvifolia leaves may offer a novel approach in the medicinal and immunological field to overcome oxidative stress as well as enhance immune responses for potential health benefits of human beings.