Abstract
Multi-resistantmicroorganisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida tropicalis e Candida krusei are the main causes of microbial infections. Padina sanctae-crucis is a seaweed often used to check the contamination of ecosystems by materials such as heavy metals, but studies of the antimicrobial activity of the same seaweed were not found. The tests for the minimum inhibitory concentration and modulation of microbial resistance, with the use of ethanolic and methanolic extracts of Padina Sanctae-cruces combined with drugs of the class of aminoglycosides and antifungal were used to evaluate the activity against the cited microorganisms. Was observed a modulation of antibiotic activity between the natural products and the E. coli and S. aureus strains, indicating a synergism and antagonism respectively. The results showed a moderate modulatory effect against some microorganisms studied.
Highlights
The World Health Organization (WHO)[1] defines medicinal plants as any plant which in one or more of its organs contains active ingredients which can be used for therapeutic purposes or contain compounds that can be used for the synthesis of useful drugs[1]
Microbial strains The bacteria used in test of Minimun Inhibitory Concentration (MIC) were the standard strains of Escherichia coli ATCC 10536, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 15442
To evaluate the modulatory activity of the natural products were used the follow multiresistants bacterial strains isolated from clinical environments: Pseudomonas aeruginosa 03, Escherichia coli 27 and Staphylococcus aureus 358
Summary
The World Health Organization (WHO)[1] defines medicinal plants as any plant which in one or more of its organs contains active ingredients which can be used for therapeutic purposes or contain compounds that can be used for the synthesis of useful drugs[1].The population of the poorest countries uses medicinal plants by symbolic tradition associated with low cost of this treatment, but in most developed countries there is an increased use of herbal medicines influenced by fad consumption of natural products[2,3].Medicinal plants and their products have been used as self-medication based on traditional knowledge[4,5,6]. The research objective was evaluate the action of spectrum and the minimum inhibitory concentration (MIC) of extracts obtained from leaves of Padina sanctae crucis against pathogenic strains of fungi and bacteria.
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