Abstract
Objective: The present study was conducted to determine the anti-asthmatic activity of Capparis decidua.Methods: The acute oral toxicity study was conducted as per OECD guidelines, and the extract was proved to be safe up to the dose of 2000 mg/kg.The anti-asthmatic activity of C. decidua was evaluated using various experimental models such as histamine-induced bronchoconstriction in guineapigs and milk-induced leukocytosis in mice, histamine-induced bronchospasm in guinea pigs, studies on pre convulsive time and milk-inducedleukocytosis in mice, studies on blood.Results: Antihistaminic drugs Chlorpheniramine maleate and ethanolic extract of C. decidua significantly protected the guinea pigs against histamineinducedbronchospasm. The ethanolic section of C. decidua has dramatically prolonged the latent period of convulsions compared to control. Ethanolicextract of C. decidua suppresses the milk-induced leukocytosis by stabilizing the oxidative stress in the surrounding tissue.Conclusion: The results obtained in the above study suggest the ethanolic extract of C. decidua possesses significant anti-asthmatic activity.
Highlights
Asthma is an allergic reaction that causes inflammation and narrowing of the respiratory tract, resulting in asthma and difficulty in breathing [1]
In the groups of guinea pigs pretreated with ethanolic extract of C. decidua (200 mg/kg, p.o.) increased the pre convulsive dyspnea (PCD) at 1st, 4th, and 24th h compared to control
Various chemical tests confirmed the presence of alkaloids, flavanoids, steroids, glycosides, tannins, and saponins in the ethanolic extract of C. decidua
Summary
Asthma is an allergic reaction that causes inflammation and narrowing of the respiratory tract, resulting in asthma and difficulty in breathing [1]. Asthma is the common chronic inflammatory disease of the airways characterized by frequent and recurrent symptoms, reversible airflow obstruction, and bronchospasm. Available treatment for asthma most medications works by relaxing bronchospasm or reducing inflammation. These available treatments are not efficient for treating asthma completely as they have many toxic and side effects. The Ayurveda suggests that herbal plants have comparatively less toxic value and are more efficacious They have fewer chances of side effects and complications to patients compared to available synthetic drug treatments [1]. Isocodonocarpine was found to be responsible for anti-inflammatory activity and anti-asthmatic activity [9,10,11,12,13,14,15]
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