Abstract
Purpose: To determine the bronchodilatory effect of ginger on histamine-induced bronchospasm in guinea pigs.
 Methods: Thirty-six guinea pigs weighing 400 - 700 g were randomly divided into six groups. Group 1 received distilled water, while group 2 was given formoterol (1.55 μg/kg) + budesonide (0.02 mg/kg). Guinea pigs in groups 3 and 4 were given ginger (350 and 700 mg/kg, respectively), while those in groups 5 and 6 received ginger (350 and 700 mg/kg, respectively) in addition to formoterol (1.55 μg/kg) and budesonide (0.02 mg/kg). Pre-convulsion time and percent protection in each group was calculated.
 Results: There was statistically significant improvement in pre-convulsion times, with values of 156.64 ± 32.93, 299.33 ± 44.20, and 235.99 ± 34.55 s for groups 2, 5 and 6, respectively (p < 0.01). Moreover, statistically significant protection values of 73 and 68 % were obtained for groups 5 and 6, respectively, relative to normal control (p < 0.01).
 Conclusion: These results indicate that ginger has promising potential for use as an add-on treatment for bronchospasm.
 Keywords: Zingiber officinale, Histamine, Asthma, Pre-convulsion time
Highlights
Asthma is characterized by chronic airway inflammation, with symptoms such as wheezing, shortness of breath, chest tightness and cough, as well as variable expiratory airflow limitation [1]
Distilled water produced no effect on the pre-convulsion time (PCT) in guinea pigs in group 1
The findings in the present study suggest potential protective effect of 5 % gingerol-based aqueous extract of Zingiber officinale Roscoe against histamineinduced bronchospasm in guinea pigs
Summary
Asthma is characterized by chronic airway inflammation, with symptoms such as wheezing, shortness of breath, chest tightness and cough, as well as variable expiratory airflow limitation [1]. Asthma causes limitations in daily activities, loss of school and work days, lung function impairment, and reduced quality of life. It is a source of huge socioeconomic burden. Ginger has been shown to possess bioactivity against respiratory ailments in various studies either by acting directly as a smooth muscle relaxant, or as an anti-inflammatory effect [7,8,9,10]. The present study was designed to evaluate the bronchodilatory effect of aqueous extract of rhizomes of Zingiber officinale Roscoe in a guinea pig model of bronchial hyperreactivity. Gingerol-based aqueous extract of Zingiber officinale Roscoe (5%) was made by Kuber Impex Ltd, Indore, Madhya Pradesh, India
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
