Abstract
Fungal organisms are an opportunistic pathogen commonly found in different parts in human body like oral cavity and vagina. Recent study has revealed a critical need for novel antifungal medicines developed from medicinal plant extracts due to concerns about fungal pathogen resistance to commercial medication. In the present work, Premna odorata Blanco, belonging to the family Lamiaceae was evaluated in vitro antifungal activity against two fungal organism isolated from clinical cases. With the aim to replace toxic conventional solvents through deep eutectic solvents was used and phytochemical compounds were determined (total phenol content, total flavonoid content). ChMa extracts of Premna odorata Blanco demonstrate a significant antifungal activity against Candida albicans, Monilinia spp. Higher than water extract. While the DES2 extract reported the highest phenolic contents (3.58 mg GAE/100 g DW) and total flavonoid content (0.028 mg RE/100 g DW) compared with water extract. In conclusion, the study suggests that the Premna odorata Blanco extracts by deep eutectic solvents are promising for the development of treatments against various fungal diseases with a friendly green procedure, low toxicity and new application in pharmaceutical industry.
Highlights
The genus Premna classified within the Lamiaceae family and subfamily Viticodeae. contains about 200 species which are naturally distributed within Africa, Australia, tropical and subtropical Asia [1]
The antifungal screening of Premna odorata Blanco extracts against Candida albicans and Monilinia spp were analyzed through disc diffusion assay
The results presented differences among the three solvents tested for plant extract in various concentrations
Summary
The genus Premna classified within the Lamiaceae family and subfamily Viticodeae. contains about 200 species which are naturally distributed within Africa, Australia, tropical and subtropical Asia [1]. Contains about 200 species which are naturally distributed within Africa, Australia, tropical and subtropical Asia [1]. Studies have reported on the ethnomedicinal values for species of Premna in Africa and Asia, notably East and Southeast Asia to treat a wide variety of human body disorders like cough, headache and some other infectious diseases [2, 3]. Many articles have been reported about Premna species that have activities against different microorganisms [5, 6]. Fungal diseases are frequent pathogens for human beings, and they may be found in every environment. Candidiasis is the most prevalent fungal disease in humans, and it causes high morbidity among individuals world-wide [7]. Monilinia spp. are fungal organisms that create economic difficulties in fruits diseases, in post harvest spoilage like brown fruit rot [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
