Abstract
Objective: The aim was to assess the effect of anti-Alzheimer’s activity of the alcoholic extract of Costus pictus D. Don Leaves in Alzheimer induce Wistar albino rats.
 Methods: In the present study, the efficacy of an Extract of Costus pictus D. Don (ECPDD) was evaluated against scopolamine-induced Alzheimer in the Wistar albino rat. Donepezil at a dose of 2.5 mg/kg, ECPDD was given in rat at a dose of 100 mg/kg body weight, 150 mg/kg body weight, and 200 mg/kg body weight. Anti-Alzheimer activity was assessed by victimization novel object recognition test, elevated plus maze, and Y-maze. And by biochemical test like neurotransmitter esterase activity, catalase activity, malonyldialdehyd and glutathione assays.
 Results: Results showed that extracts treatment prevents Alzheimer and increases the level of acetylcholine, catalase, glutathione peroxidase, and phytochemical studies identified the presence of flavonoid and alkaloid in the ECPDD.
 Conclusion: According to the results, it was concluded that the leave of C. pictus D. Don has significant anti-Alzheimer activity due to the presence of potent antioxidants such as flavonoid and anticholinesterase enzyme present in alkaloids.
Highlights
Alzheimer’s disease (AD) was discovered in 1906 by Alois Alzheimer, a German brain scientist
An abnormal number of additional phosphates are added to the tau protein, causing the tau proteins to release from the microtubules, inflicting the tau proteins to unharnessed from the microtubules
There is no cure for AD, the drugs currently used are tacrine hydrochloride (Cognex) and donepezil hydrochloride (Aricept), rivastigmine, and galantamine [7]
Summary
Alzheimer’s disease (AD) was discovered in 1906 by Alois Alzheimer, a German brain scientist. The sickness was initially ascertained during a 51-year-old lady named Auguste D Her family brought her to Dr Alzheimer in 1901 once noticing changes in her temperament and behavior. An abnormal number of additional phosphates are added to the tau protein, causing the tau proteins to release from the microtubules, inflicting the tau proteins to unharnessed from the microtubules These hyperphosphorylated proteins bind with each other and type tangles among the cell, referred to as NFT [6]. The ordinary yield and class are not reasonable due to slow development degree, overexploitation, and environment demolition which are possibly the key drawbacks to see the ever-growing marketplace request Additional, farming of these rough therapeutically significant plants lacks satisfactory illnessfree elite implanting resources due to great vulnerability of the crop for rhizome rot, leaf spot, and microbial wilt [9]. Don possesses the anticholinesterase activity and they decrease the breakdown of acetylcholine so may help in treating Alzheimer diseases [10]
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