Abstract
Testosterone (T) plays an essential role in properly developing and maintaining male reproductive tissues (1). The normal serum testosterone levels can vary between 300 to 1000 ng/dL. However, it is unclear whether androgen receptor signaling can vary based on serum T levels. What remains unknown is whether there is a consistent serum T level above which androgen receptor signaling within the tissue remains similar. Therefore, we evaluated whether varying serum levels of T alter androgen receptor (AR) signaling in human penile tissue.
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