Abstract
Antioxidant activity of phenolic and flavonoid fractions of Cleome gynandra and Maerua angolensis of Burkina FasoMeda N.T.R., Bangou M.J., Bakasso S., Millogo-Rasolodimby J. and O.G. Nacoulma
Highlights
Pain is a disabling supplement of many medical conditions worldwide (Schim and Stang, 2004)
This study investigated the possible antinociceptive action of the petroleum ether/ethyl acetate extract and fractions prepared from the stem barks of Maerua angolensis
The acetic acid-induced abdominal writhing, formalin–induced nociception, prostaglandin E2–induced mechanical hyperalgesia, bradykinin– and epinephrineinduced thermal hyperalgesia tests as well as Paw withdrawal test using Hargreaves thermal hyperalgesia model were used to assess the antinociceptive effects of the extract and the fractions after oral administration in rodents
Summary
Pain is a disabling supplement of many medical conditions worldwide (Schim and Stang, 2004). It is the major cause of all first visits to hospitals for consultations and the most common symptom of disease or injury (Porth, 2011). The use of opioids and non-steroidal antiinflammatory drugs (NSAIDs) are associated with side effects such as gastric ulcerations and tolerance coupled with the fact that they are not effective in neuropathic pain. This has necessitates the need to search for potent and safe analgesics. Information on the median lethal dose (LD50) of the stem bark extract of the plant in mice revealed LD50 of 3,807.9 mg/kg orally (p.o.) and greater than 500 mg/kg intraperitoneally (i.p.) (Magaji et al, 2008) suggesting relative safety of the stem bark
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