Abstract
The plant Breynia rhamnoides Muell. Arg (family-Phyllanthaceae/Euphorbiaceae) was reported to have numerous potent constituents and the same plant was used for many traditional medicines. Phytochemical analysis of ethanolic extracts of Breynia rhamnoides revealed the presence of many active compounds such as flavonoids, glycosides, phenolic compounds, terpenoids, steroids and saponins. Present work describes the extraction and evaluation of analgesic and anti-inflammatory activities of aerial part extract of Breynia rhamnoides . Acute toxicity studies were performed as per OECD-423 guidelines. Toxicity signs and symptoms were not observed. Anti-inflammatory activity was evaluated by carrageenan-induced paw edema model and analgesic activity by Eddys hot plate method and Acetic acid induced writhing method in Wistar albino rats. The extract exhibited significant anti- inflammatory and peripheral analgesic activity.
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