Evaluation of Adipokines, Inflammatory Markers, and Sex Hormones in Simple and Complex Breast Cysts' Fluid.

Paweł Madej,Grzegorz Franik,Magdalena Olszanecka-Glinianowicz,Aleksander Owczarek,Jerzy Chudek,Piotr Kurpas

doi:10.1155/2016/5174929

Abstract

Objective. The aim of the study was to analyze the association between levels of adipokines in the breast cyst fluid and in the circulation in relation to the type of cysts. Material and Measurements. A cross-sectional study involved 86 women with breast cysts (42 with simple cysts and 44 with complex cysts). Plasma and breast cyst fluid leptin, adiponectin, visfatin/NAMPT, resistin, TNF-α, and IL-6 levels, in addition to serum levels of estradiol, progesterone and prolactin, and anthropometric parameters and body composition (by bioimpedance method), were measured. Results. The levels of leptin, adiponectin, and resistin were significantly lower in breast cyst fluid than in plasma regardless of the cyst type. Contrarily, the levels of visfatin/NAMPT and TNF-α were significantly increased, and IL-6 levels were similar in the breast cyst fluid and plasma in both study groups. There was no correlation between corresponding levels of leptin, adiponectin, resistin, visfatin/NAMPT, TNF-α, and IL-6 in breast cyst fluid and plasma. Conclusions. Higher levels of visfatin/NAMPT and TNF-α in the fluid from simple and complex breast cysts than in plasma suggest that their local production is related to inflammation.

Highlights

Fibrocystic disease in women is a benign breast disease, known as mastopathy, cystic degeneration or breast fibrocystic dysplasia that constitutes approximately 55% of benign breast lesions [1].The disease occurs in 7% of women, usually about 40 years old, and detected cysts are often multiple and bilateral
Our study revealed the lack of differences in estradiol, progesterone, and prolactin levels between women with simple and complex cysts
There is the lack of studies assessing the differences between serum sex hormones levels in women with simple and complex cysts

Summary

Introduction

Fibrocystic disease in women is a benign breast disease, known as mastopathy, cystic degeneration or breast fibrocystic dysplasia that constitutes approximately 55% of benign breast lesions [1].The disease occurs in 7% of women, usually about 40 years old, and detected cysts are often multiple and bilateral. The pathological changes in the breast involve connective and fat tissues, epithelium lining ducts, and glandular follicles with a tendency to the formation of fluid-filled cysts. It is long-standing disease that may occur with or without cell proliferation and atypia and predispose to breast cancer development. The established method of differentiating cysts from solid masses is breast sonography. A complex breast cyst is characterized by a presence of internal echoes, thin septations, an intracystic mass, or a perceptible wall or by the absence of definitive posterior wall enhancement [4]

Methods

Results

Conclusion