Evaluation of adipokine chemerin in hypertensive obese

Dalia Ramzy Ibrahim,Amaal Mohamed Kamal,Mervat Elsayed Taha

doi:10.14393/bj-v35n6a2019-47937

Dalia Ramzy Ibrahim, Amaal Mohamed Kamal + Show 1 more

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https://doi.org/10.14393/bj-v35n6a2019-47937

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Abstract

Chemerin is an adipokine secreted by adiopose tissue and has a role in obesity and hypertension. This study aims at assessing the level of the adipokine chemerin in obesity and/or hypertension and correlating its level with the inflammatory marker hs-CRP and predictors of atherosclerosis as lipid profile, insulin resistance, systolic (SBP) and diastolic blood pressure (DBP).Volunteers were divided into 4 equal groups according to body mass index (BMI) and blood pressure: normal weight group (BMI ≤ 24.9 kg/m2), overweight group (BMI = 25.0 – 29.9 kg/m2), normotensive obese group (BMI ≥ 30.0 kg/m2) and hypertensive obese group (BMI ≥ 30.0 kg/m2). Chemerin, high-sensitivity C-reactive protein (hs-CRP), lipid profile, fasting blood glucose (FBG) and fasting insulin (FI) were evaluated in the mentioned groups.The results showed that there were significant increases of chemerin, hs-CRP, low density lipoprotein (LDL), SBP and DBP in hypertensive obese group compared to normotensive obese , overweight and normal weight groups. Moreover the only significant positive correlation between chemerin and hs-CRP was observed in the obese hypertensive group. The normotensive obese group showed significant increases of hs-CRP, LDL, triglyceride (TG), FBG, FI and the homeostasis model assessment-insulin resistance index (HOMA-IR) compared to the overweight and normal weight groups. Regarding the overweight group, there were significant increases in chemerin, hs-CRP, cholesterol, LDL, TG compared to the normal weight group, while the HDL levels were significantly lower compared to the two obese groups. These results revealed that the pro-inflammatory adipokine chemerin increases in obesity associated with hypertension, leading to the suggestion that there is a definite dysregulation of the pro-inflammatory and anti-inflammatory parameters towards the pro-inflammatory when hypertension and obesity are associated.

Highlights

Adipose tissue is a metabolically active organ, as it secretes various adipokines and cytokines (RONDINONE, 2006)
To clarify the effect of obesity, the percentage of change 1 was calculated between each of the overweight and normotensive obese group, and the normal weight group, while to evaluate the effect of hypertension, the percentage of change 2 was analyzed between the hypertensive and the normotensive obese groups
The systolic BP (SBP) and diastolic blood pressure (DBP) significantly increased in hypertensive obese group compared to the normotensive obese and the percentage of change between them was 18% and 13% respectively

Summary

Introduction

Adipose tissue is a metabolically active organ, as it secretes various adipokines and cytokines (RONDINONE, 2006). Excess white adipose tissue (WAT) in obesity is characterized by dysregulation of pro-inflammatory and antiinflammatory adipokines. This disequilibrium can induce a chronic inflammatory state and act as a pathogenic link between obesity and many diseases such as type 2 diabetes mellitus, dyslipidemia, hypertension and coronary heart disease (BULLO et al, 2007; MAURY; BRICHARD, 2010; FERNANDEZ-SANCHEZ et al, 2011). Chemerin is one of the pro-inflammatory adipokines that is secreted in an inactive form as prochemerin and activated through proteolytic cleavage (WANG; NAKAYAMA, 2010). Glucose metabolism and inflammation, it recruits and activates immune cells (JOHN et al, 2007; ROURKE et al, 2013). The serum level of chemerin was associated with aortic stiffness in healthy individuals (HOO et al, 2012)

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