EVALUATION OF A CORRELATION BETWEEN SLEEP HOURS, SLEEP QUALITY AND SALIVARY LEVELS OF 8-HYDROXY-2'-DEOXYGUANOSINE IN CHRONIC PERIODONTITIS PATIENTS- AN OBSERVATIONAL STUDY

Abstract

Aims: To determine if there was a correlation between sleep hours, sleep quality with the salivary levels of 8-hydroxy-2’-deoxyguanosine in chronic periodontitis patients, and to decide its relationship with the established clinical periodontal parameters. Settings and Design: Observational analytical study with 100 patients based on the inclusion criteria, who visited the Department of Periodontology of a tertiary care setting. Methods and Material: Bleeding on probing, pocket depth, clinical attachment loss, plaque index score were recorded. Sleep behaviour longer than a month time stretch was surveyed by Pittsburgh Sleep Quality Index, a validated questionnaire. 8-OHdG levels in un-stimulated saliva of all subjects were examined by ELISA. Statistical analysis used: Sleep-hour correlations with sleep quality at salivary 8-OHdG levels as well as clinical periodontal parameters were assessed using the Pearson correlation coefficient. All statistical analysis was performed using SPSS software version 17.0. Results: Salivary 8-OHdG levels and clinical parameters (PPD, CAL, PI) were significantly higher among sleep deprived individuals. On comparison, subjects with a poor quality of sleep (PSQI score>5) showed a significantly higher 8-OHdG levels. Conclusions: Short sleep durations and poor sleep quality can instigate inflammation and oxidative stress and could be a risk factor for periodontitis.