Abstract
Background Radiofrequency ablation (RFA) has the similar curative effects to surgery, but RFA will lead to higher postoperative local recurrence rate. 3D-CEUS is a minimally invasive examination method, which is used to analyze the sensitivity to postoperative recurrence in this study. Methods The clinical data of 60 patients with liver cancer admitted to our hospital (February 2018-February 2020) were retrospectively analyzed. All patients were treated with RFA and were followed up with 3D-CEUS, MRI, and enhanced CT examination after surgery. The ROC curve was used to analyze the differences of different examination methods in judging postoperative recurrence. Results For the 60 patients, 52 patients (86.7%) had a single lesion and 8 patients (13.3%) had multiple lesions, with a total of 72 lesions. After RFA, 56 lesions (77.8%) were completely inactivated and 16 lesions (22.2%) remained. Totally inactivated lesions were detected as follows: 51 (91.1%) by 3D-CEUS, 42 (75.0%) by MRI, and 50 (89.3%) by enhanced CT. During a 2-year follow-up, a total of 26 recurrent lesions were detected, 24 (92.3%) by 3D-CEUS, 12 (46.2%) by MRI, and 25 (96.2%) by enhanced CT, indicating that the sensitivity of 3D-CEUS and enhanced CT was obviously higher than that of MRI (P < 0.001), without conspicuous difference between sensitivity of 3D-CEUS and enhanced CT (P > 0.05). Conclusion As a new imaging examination method based on artificial intelligence, 3D-CEUS has a high sensitivity in patients with liver cancer who underwent RFA, which can effectively judge the recurrence after surgery and should be widely used in practice.
Highlights
Liver cancer mainly includes primary and secondary types, among which primary liver cancer originates from epithelial or mesenchymal tissue of liver, while secondary liver cancer is caused by invasion of other malignant tumors to liver
With less influence by the operator, enhanced CT is regarded as the reliable standard for examination of liver cancer after Radiofrequency ablation (RFA) [18]. is study showed that, by enhanced CT examination, totally inactivated lesions were detected as 50 (89.3%) and recurrent lesions were detected as 25 (96.2%), which was close to the general findings in the academic community
3D-contrastenhanced ultrasound (CEUS) has a high sensitivity in patients with liver cancer who underwent RFA, which can effectively judge the recurrence after surgery and should be widely used in practice
Summary
Liver cancer (liver malignant tumor) mainly includes primary and secondary types, among which primary liver cancer originates from epithelial or mesenchymal tissue of liver, while secondary liver cancer is caused by invasion of other malignant tumors to liver. RFA is physical ablation treatment method, which is minimally invasive and repeatable, and can improve the safety of liver cancer. 3D-CEUS is a minimally invasive examination method, which is used to analyze the sensitivity to postoperative recurrence in this study. All patients were treated with RFA and were followed up with 3DCEUS, MRI, and enhanced CT examination after surgery. Inactivated lesions were detected as follows: 51 (91.1%) by 3D-CEUS, 42 (75.0%) by MRI, and 50 (89.3%) by enhanced CT. As a new imaging examination method based on artificial intelligence, 3D-CEUS has a high sensitivity in patients with liver cancer who underwent RFA, which can effectively judge the recurrence after surgery and should be widely used in practice
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