Abstract
Objective To detect the male bladder outlet obstruction concurrency model nerve growth factor(NGF) expression levels in patients with overactive bladder(OAB) urine, to analyze model NGF to DO type OAB and not DO type differential diagnosis value of OAB, and explore model NGF to relieve obstruction surgery effect assessment of the value. Methods Thirty normal males were set as group A, and 77 patients with bladder outlet obstruction(BOO) in the experimental group underwent urodynamic examination. According to the results of the urodynamic examination, only 22 cases of BOO group were group B. There were 55 cases of BOO combined with OAB symptoms in group C, of which 32 cases of urodynamic performance with type OAB in group C1. Twenty-three cases of non-DO OAB was group C2. The patients in group B and C were all assessed, including IPSS, OABSS and urodynamic pressure flow rate. The serum NGF expression level was detected by ELISA method, and the results were standardized with the urine specimen of creatinine (Cr). Results The expression levels of the NGF/Cr were group A: (0.005±0.002), group B: (0.011±0.008), C1: (0.909±0.324), C2: (0.919±0.447). The group B and C were 0.302 and 0.001 compared with group A. There was no significant difference between group A and group B, but there was significant difference between group A and group B. In patients with prostate surgery, the NGF/Cr was (0.901±0.382), (0.061±0.017) before and after surgery (P=0.024). The NGF level was significantly reduced after the operation. There was no significant difference between group C1 and C2 (P=0.283), NGF/Cr remained high in 5 cases (16.7%) by scatter plots. Conclusions NGF is a diagnostic indicator of male BOO with OAB, but there is no statistically significant difference between the type OAB and non-DO OAB. At the same time, NGF has good application value as an auxiliary evaluation index for the improvement of OAB symptoms. Key words: Urinary Bladder Neck Obstruction; Urinary Bladder, Overactive; Nerve Growth Factors
Published Version
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