Abstract
Background: In many countries as well as some oncology centers in Vietnam, three-dimensional conformal radiation therapy (3D-CRT) plus chemotherapy has been the standard treatment in esophageal cancer. This study aimed at evaluating the clinicopathological characteristics and treatment results of patients who underwent concurrent chemoradiotherapy for stage II-III esophageal cancer at Hanoi Oncology Hospital. Method: Descriptive, retrospective study of 36 patients who underwent concurrent chemoradiotherapy for stage II-III esophageal cancer at Hanoi Oncology Hospital from June 2018 to December 2019. Results: Mean age was 57.4 years old. Ratio male:female = 17:1. Most tumors were ulcerated masses (56.4%). 77.8% had middle-third tumors. 75% were in stage IIIA, 25% in stage II. 90.9% improved symptoms of dysphagia. Complete response, partial response and stable disease rates were 33.3%, 55.6% and 8.3%, respectively. One patient had disease progression. Median progression free survival was 18.1 months. Early toxicities: esophagitis 41.7%, skin fibrosis 91.7%. Late toxicity: esophageal stricture 47.2%. Conclusions: 3D-CRT plus concurrent chemotherapy is effective in treating stage II, III esophageal cancer with acceptable toxicities.
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