Abstract
e16561 Background: Esophageal stenosis after curative treatment of esophageal cancer (CE) by radiochemotherapy has a high incidence, causing great impact to the patient’s health. Identifying risk factors for this type of pathology may provide earlier diagnosis and more effective follow-up for patients with CE undergoing curative radiotherapy. The objective of this study was to determine the risk factors for esophageal stenosis in patients with complete regression of the tumor lesion after advanced CE treatment with radiotherapy associated or not with chemotherapy. The choice of the theme is justified because there are no studies on esophageal stenosis after radiotherapy associated or not with chemotherapy in esophageal cancer in the west. Methods: Retrospective observational study with 103 patients of both sexes who presented total regression of esophageal squamous cancer, confirmed by endoscopy and biopsies, after treatment with or without chemotherapy. The relationship between the sexes, age, tumor staging, involvement of the esophageal circumference, tumor location, isolated use of radiotherapy or associated chemotherapy, and tumor extension with or without stenosis and its degree after treatment with total regression of the tumor. Results: Most patients are male (58.3%). There was a direct relationship between the degree of circumference involvement and the degree of stenosis and a significant association between tumor location and degrees of stenosis (p < 0.001). The higher the degree of posttreatment stenosis, the higher the percentage of more advanced tumors (p < 0.001). Regarding tumor extension, the greater the degree of stenosis after treatment, the greater the proportion of tumors larger than 60 mm (p < 0.001). T3 tumors increase in 23.77 chance of post-treatment stenosis compared to T2 tumors. T4 tumors, increase the chance of presenting post-treatment stenosis 23.94 times compared to T2 tumors. Conclusions: Our data show that impaired esophageal circunference, tumor extension, advanced stages, and pretreatment tumor stenosis are factors related to esophageal stenosis following treatment with advanced radiochemotherapy for esophageal cancer.
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